Born in Watertown, NY, Reginald Case's work was represented by Allan Stone Gallery, NYC for many years where he had several One Man Shows and was included in numerous Group Exhibitions. He has also had major museum exhibitions of his work shown at Munson-Williams-Proctor Institute, Utica,NY, Everson Museum, Syracuse, NY, Virginia Museum of Fine Art, Richmond, VA, and Reading Museum, Reading, PA.

His work is represented in many private and public collections, including The Victoria and Albert Museum, London, The British Museum, London, The Solomon R.Guggenheim Museum, NYC, Boston Museum Of Fine Art, Boston, MA, Smithsonian American Art Museum, Washington D.C., The Jewish Museum, NYC, The Fogg Art Museum, Harvard University, Cambridge, MA., Jewish Museum of Belgium, Brussels, Belgium and Museum Dr. Guislain, Ghent, Belgium. Reginald Case is the recipient of numerous awards and fellowships.